CYP2R1 CLIA Kit for Human(Homo sapiens) | EIAab.comCYP2R1 CLIA Kit for Human(Homo sapiens)

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Index > Protein center > CYP2R1(Gene name) > Human

CYP2R1 (Gene name),

Vitamin D 25-hydroxylase (Protein name ), CP2R1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CYP2R1;

Protein name:

Vitamin D 25-hydroxylase;

Alternative:

Cytochrome P450 2R1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer.

Function:

Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3).

Subcellular Location:

Endoplasmic reticulum membrane Peripheral membrane protein Microsome membrane Peripheral membrane protein

Protein Attributes:

Sequence length:

501

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

501:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q6VVX0

MIM:

600081

Pfam:

PF00067

UniGene:

Hs.371427

KEGG:

hsa:120227

SMR:

Q6VVX0

STRING:

9606.ENSP00000334592

Uniprot:

Q6VVX0

FOR

ELISA Kit for Human Vitamin D 25-hydroxylase

Cat.:

E15523h

Price:

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MSDS:

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Packing:

96T

ELISA Kit for Human Vitamin D 25-hydroxylase

Cat.:

E15523m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Vitamin D 25-hydroxylase

Cat.:

U15523m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Vitamin D 25-hydroxylase

Cat.:

U15523h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Vitamin D 25-hydroxylase

Cat.:

P15523Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Vitamin D 25-hydroxylase

Cat.:

P15523Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Vitamin D 25-hydroxylase

Protein for Human Vitamin D 25-hydroxylase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxylase."
Cheng J.B. , Motola D.L. , Mangelsdorf D.J. , Russell D.W.
J. Biol. Chem.278:38084-38093(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;CATALYTIC ACTIVITY
2.

"Metabolism of vitamin D by human microsomal CYP2R1."
Shinkyo R. , Sakaki T. , Kamakura M. , Ohta M. , Inouye K.
Biochem. Biophys. Res. Commun.324:451-457(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Liver.
4.

"Human CYP2R1 gene 5'-flanking region."
Tsuruga E. , Bell N.H. , Reddy S.V.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-8
5.

"Structural analysis of CYP2R1 in complex with vitamin D3."
Strushkevich N. , Usanov S.A. , Plotnikov A.N. , Jones G. , Park H.-W.
J. Mol. Biol.380:95-106(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 32-501 IN COMPLEX WITH VITAMIN D3 AND HEME;FUNCTION;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;SUBUNIT
6.

"Crystal structure of CYP2R1 in complexes with 1-alpha-hydroxy-vitamin D2 and with vitamin D2."
Structural genomics consortium (SGC)
Submitted (2009-02) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.72 ANGSTROMS) OF 32-501 IN COMPLEXES WITH HEME; VITAMIN D2 AND 1-ALPHA-HYDROXY-VITAMIN D2
7.

"Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase."
Cheng J.B. , Levine M.A. , Bell N.H. , Mangelsdorf D.J. , Russell D.W.
Proc. Natl. Acad. Sci. U.S.A.101:7711-7715(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VDDR1B PRO-99

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